Updating on the pathogenesis of systemic lupus erythematosus

Multiple genes contribute to disease susceptibility. The interaction of sex, hormonal milieu, and the hypothalamo–pituitary–adrenal axis modifies this susceptibility and the clinical expression of the disease.Defective immune regulatory mechanisms, such as the clearance of apoptotic cells and immune complexes, are important contributors to the development of SLE.An association of HLA DR2 and DR3 with SLE is a common finding in patients of different ethnicities, with a relative risk for the development of disease of approximately two to five.The HLA class II genes have also been associated with the presence of certain autoantibodies such as anti-Sm (small nuclear ribonuclear protein), anti-Ro, anti-La, anti-n RNP (nuclear ribonuclear protein), and anti-DNA antibodies.

In order to use Medscape, your browser must be set to accept cookies delivered by the Medscape site.However, in most cases, consistent results could not be obtained in subsequent studies in different ethnic groups.Some of these polymorphic genes may confer risk to certain subsets of patients with SLE.The loss of immune tolerance, increased antigenic load, excess T cell help, defective B cell suppression, and the shifting of T helper 1 (Th1) to Th2 immune responses leads to B cell hyperactivity and the production of pathogenic autoantibodies.

Updating on the pathogenesis of systemic lupus erythematosus comments

  • The Pathogenesis of Systemic Lupus Erythematosus – An Update profil de paulette60


    Nov 3, 2012. Systemic lupus erythematosus SLE, lupus is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE.…
  • Patient education Systemic lupus erythematosus SLE Beyond the. profil de paulette60


    This topic last updated Feb 27, 2018. SYSTEMIC LUPUS ERYTHEMATOSUS OVERVIEW. Systemic lupus erythematosus also known as lupus or SLE is a chronic inflammatory disease that can affect various parts of the body. Lupus is an autoimmune condition, meaning that your body's immune system attacks your own.…
  • Systemic Lupus Erythematosus - eLS - Schur - Wiley Online Library profil de paulette60


    Jul 15, 2015. The following observations are compatible with a genetic role in the pathogenesis of SLE Schur, 1995 1 there is a high concordance rate 14–57% of SLE in monozygotic twins and 2 5–12% of relatives of patients with SLE have the disease. A genetic predisposition for the development of SLE is also.…